OFFICIAL HIGHLIGHTS

American Diabetes Association

Conference summaries


Dermatosurgery

Update in dermatosurgery

Presented by: Prof. Eduardo Nagore Department of Dermatology, Instituto Valenciano de Oncología, Valencia, Spain
  • Functional surgery can now be considered as the treatment of choice for thin subungual tumours.
  • Immunosuppressed patients carry an increased risk of complications in dermatosurgery.
  • In dermatofibrosarcoma protuberans, fibrosarcomatous areas are predictive of high risk for recurrence and distant metastasis, and patients harbouring such lesions require intensive follow-up.

As with other disciplines, in dermatosurgery innovation is giving rise to improved treatment outcomes. High-quality and guideline-based treatment of surgical patients must not be limited to the actual surgical procedure and its challenges with respect to surgical technique and reconstructive defect closure. In order to ensure the success of a surgical procedure, a number of perioperative aspects have to be considered.

  • When considering novelties in the surgical procedure itself, at least 3 aspects should be mentioned: anaesthesia, imaging and surgical technique.
  • Regarding anaesthesia, there is a paucity of data that directly compare outcomes, complications, and costs between general and local anaesthesia in cutaneous surgery. [1]
  • Given the relative risks of procedures performed under general anaesthesia and the consistently comparable outcomes with significantly lower costs of procedures performed under local anaesthesia, it has been recently suggested that local anaesthetic techniques should be used whenever possible.
  • However, careful consideration of the individual needs and comfort level of the patient should still be given when choosing anaesthesia.
  • Imaging techniques is another area that is receiving increasing attention. [1]
  • For example, frozen histological sections are routinely used for intraoperative margin assessment during Mohs surgery, although fluorescence confocal microscopy (FCM) is a new tool that offers a promising and faster alternative. [2]
  • High levels of accuracy for FCM vs. frozen section have been demonstrated in intraoperative margin assessment for basal cell carcinoma (BCC) during Mohs surgery. [2]
  • Even if at present some technical issues may hinder prevent the widespread use of FMC, new devices have the potential to overcome these limitations.
  • Rapid lump examination is another new technique that allows for rapid 3-dimensional visualisation of surgical margins for detection of residual BCC, and holds potential to speed up histologic examination during micrographic Mohs surgery. [3]
  • The technique has good sensitivity and specificity compared to traditionally-stained frozen sections.
  • Several refinements in surgical technique have also been reported in recent years.
  • One example is the use of functional surgery for in situ or minimally invasive nail melanoma, which has now been demonstrated to be the technique of choice over amputation. [4]
  • Another example is modified shave surgery combined with the nail window technique, which is now preferred for longitudinal melanonychia as it is associated with limited postoperative nail dystrophy and low rates of recurrence of pigmentation. [5]
  • Despite the large number of dermatological procedures performed, there is still limited information about surgical site infections (SSI) in the absence of antibiotic prophylaxis.
  • A recent analysis found that the risk of acquiring an SSI is increased in surgeries on the ear, in larger wounds and in defects closed with flaps or healed by secondary intention. [6]
  • In Mohs micrographic surgery, retrospective assessment of postoperative complications has shown that immunosuppression places patients at higher risk for postoperative complications, including SSI and wound dehiscence. [6]
  • A model was recently established for predicting SSI in dermatological surgery which shows that about 8 patients should be treated with antibiotic prophylaxis in order to avoid one infection. [7]
  • Mohs micrographic surgery is an important and effective treatment modality for cutaneous melanoma.
  • A recent prospective, multicentre, cohort study of 562 melanomas treated with MMS reported that the procedure with melanoma antigen recognised by T cells 1 immunostaining safely provides tissue conservation and same-day reconstruction of histologically verified tumour-free margins. [8]
  • Moreover, when comprehensive margin evaluation is not applied, initial surgical margins of at least 10 mm for primary trunk/extremity and 12 mm for head/neck melanomas should be used to achieve histologically negative margins 97% of the time.
  • A large study on over 70,000 patients also demonstrated that Mohs surgery may provide an alternative approach to traditional wide margin excision for appropriately selected cases of AJCC-8 stage I melanoma without compromising patient survival. [9]
  • An analysis of the SEER database reported that declining surgery, especially among the elderly, is associated with poorer survival outcomes, highlighting the need to provide better patient education and support for optimal management. [10]
  • In squamous cell carcinoma, Mohs surgery is also a highly effective treatment considering long-term outcomes and may mitigate factors typically considered at high risk such as T-stage. [11]
  • Tumour invasion beyond subcutaneous fat and poor histologic differentiation may carry a greater risk of poor outcomes than other factors in high risk disease.
  • Mohs surgery alone still provides excellent marginal control with low rates of local recurrence, nodal metastasis and disease-specific death.
  • In dermatofibrosarcoma protuberans, several risk factors for local recurrence have recently been identified following Mohs micrographic surgery, the most important of which is fibrosarcomatous changes, associated with a 13-fold increased risk, in addition to tumour size >5 cm. [12]
  • Thus, clinicians should be aware of these features in addition to emphasising intensive self-examination.
  • Another recent study found that fibrosarcomatous change was associated with a 20-fold increased risk of recurrence along with positive resection margins. [13]
  • These studies underline that follow-up should be proactive and individualised based on the patient, tumour and histopathological findings.
  • In atypical fibroxanthoma, a systematic review and meta-analysis has suggested that recurrence rates are similar between Mohs micrographic surgery and wide local excision techniques and that timing of recurrence is similar regardless of surgical technique employed. [14]
  • A recent retrospective case series investigated the advantages and indications of using split-thickness skin-grafts (STSG) to reconstruct auricular concave surfaces after Mohs surgery. [15]
  • A total of 16 patients with defects on the auricular concavities resulting from removal of non-melanoma skin cancer were reconstructed with STSG taken from the adjacent hairy skin.
  • Only one patient experienced partial graft failure and no other complications were observed after 6-month follow-up.
  • STSG were thus considered to be suitable for reconstructing concave areas in the ear, providing good cosmetic results.
  • Choosing the adjacent hairy skin as a donor area further shortens the operative and postoperative time, and allows the procedure to be performed in a single surgical field.
  • Efforts to improve scar appearance have also been reported with laser treatment during early wound healing.
  • Subtle improvements have been documented compared to untreated control scars, although there was a low degree of correspondence between on-site, photo and patient assessments.
  • Confocal microscopy seems promising for margin assessment during Mohs surgery.
  • Rapid lamp examination is a fast and promising technique.
  • There is a need for at least a 1 cm margin for in situ/thin melanoma.
  • Mohs surgery is a good option for melanoma surgery and is associated with low rates of local recurrence.
  • Non-ablative fractional laser treatment may be useful to improve cosmetic outcomes in surgical scars.

Key messages/Clinical perspectives

  • Functional surgery is the treatment of choice for thin subungual tumours, and is associated with better cosmetic and functional outcomes vs. amputation.
  • Immunosuppressed patients are at increased risk of surgical complications.
  • Fibrosarcomatous areas in dermatofibrosarcoma protuberans indicate a very high risk for recurrence and distant metastasis, while low-risk lesions may not require intensive follow-up.


References

References


  1. Locke MC, Davis JC2, Brothers RJ, et al. Assessing the outcomes, risks, and costs of local versus general anesthesia: A review with implications for cutaneous surgery. J Am Acad Dermatol. 2018 May;78(5):983-8.
  2. Longo C, Pampena R, Bombonato C, et al. Diagnostic accuracy of ex ivo fluorescence confocal microscopy in Mohs surgery of basal cell carcinomas: A prospective study on 753 margins. Br J Dermatol. 2019 Jun;180(6):1473-80.
  3. Moehrle M, Käflein L, Ziefle S, et al. Rapid lump examination (RLE) - a new tool for Mohs surgery? J Dtsch Dermatol Ges. 2011 Jul;9(7):534-8.
  4. Jo G, Cho SI, Choi S, et al. Functional surgery versus amputation for in situ or minimally invasive nail melanoma: A meta-analysis. J Am Acad Dermatol. 2019 Oct;81(4):917-22.
  5. Zhou Y, Chen W, Liu ZR, et al. Modified shave surgery combined with nail window technique for the treatment of longitudinal melanonychia: Evaluation of the method on a series of 67 cases. J Am Acad Dermatol. 2019 Sep;81(3):717-22.
  6. Liu X, Sprengers M, Nelemans PJ, et al. Risk factors for surgical site infections in dermatological surgery. Acta Derm Venereol. 2018 Feb 7;98(2):246-50.
  7. Liu X, Kelleners-Smeets NWJ, Sprengers M, et al. A clinical prediction model for surgical site infections in dermatological surgery. Acta Derm Venereol. 2018 Jul 11;98(7):683-8.
  8. Ellison PM, Zitelli JA, Brodland DG. Mohs micrographic surgery for melanoma: A prospective multicenter study. J Am Acad Dermatol. 2019 Sep;81(3):767-74.
  9. Cheraghlou S, Christensen SR1, Agogo GO, et al. Comparison of survival after mohs micrographic surgery vs wide margin excision for early-stage invasive melanoma. JAMA Dermatol. 2019 Sep 25. doi: 10.1001/jamadermatol.2019.2890.
  10. Elias ML, John AM, Weisberger JS, et al. Declining recommended surgery in primary cutaneous melanoma: an analysis of risk factors and survival. J Eur Acad Dermatol Venereol. 2019 Jul;33(7):e253-4.
  11. Tschetter AJ, Campoli MR, Zitelli JA, et al. Long-term clinical outcomes of patients with invasive cutaneous squamous cell carcinoma treated with Mohs surgery: a five-year, multicenter, prospective cohort study. J Am Acad Dermatol. 2019 Jul 3. pii: S0190-9622(19)32302-3.
  12. Li Y, Wang C, Yang K, Peng S, et al. Clinical features of dermatofibrosarcoma protuberans and risk factors for local recurrence after Mohs micrographic surgery. J Am Acad Dermatol. 2019 Sep 24. pii: S0190-9622(19)32779-3.
  13. Huis In ‘t Veld EA, van Coevorden F, Grünhagen DJ, et al. Outcome after surgical treatment of dermatofibrosarcoma protuberans: Is clinical follow-up always indicated? Cancer. 2019 Mar 1;125(5):735-41.
  14. Phan K, Onggo J. Time to recurrence after surgical excision of atypical fibroxanthoma-updated systematic review and meta-analysis. Australas J Dermatol. 2019 Aug;60(3):e220-2.
  15. Querol E, García-Martínez J, Redondo P. Split-thickness skin grafts obtained from adjacent hairy skin for reconstructing auricular concave surfaces after Mohs surgery. J Eur Acad Dermatol Venereol. 2019 Sep 30. doi: 10.1111/jdv.15982.

Presenter disclosure information: E Nagore: None.

Medical writer: Patrick Moore, PhD

Reviewer: Martina Lambertini, MD

Local reviewers: Martina Lambertini, MD (Italian); Alain Brassard, MD (French); Jorge Moreno González, MD (Spanish); Swen Malte John, MD, PhD (German); Marcelo Arnone, MD (Portuguese)

Scientific Editor: Prof. Brigitte Dréno, MD


CLINICAL TRIALS

PSORIASIS

Efficacy and safety of ixekizumab in a phase 3, randomized, double-blind, placebo-controlled study in paediatric patients with moderate-to-severe plaque psoriasis

Presented by: Prof. Kim A. Papp, Department of Medicine, Division of Dermatology, University of Toronto, Toronto, Canada

ATOPIC DERMATITIS

Efficacy and safety of baricitinib in combination with topical corticosteroids in moderate to severe atopic dermatitis: results of a phase 3 randomized, double-blind, placebo-controlled 16-week trial (BREEZE-AD7)

Presented by: Prof. Kristian Reich, Translational Research in Inflammatory Skin Diseases, Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, and Skinflammation® Center, Hamburg, Germany

PRURIGO NODULARIS

Phase 2b study of nemolizumab in patients with moderate to severe prurigo nodularis and associated severe pruritus

Presented by: Prof. Sonja Ständer, Department of Dermatology and Center for Chronic Pruritus (KCP), University Hospital Münster, Germany

VITILIGO

Efficacy and safety of a 52-week, randomized, double-blind trial of ruxolitinib cream for the treatment of vitiligo

Presented by: Dr. Amit G. Pandya, University of Texas Southwestern Medical Center, Dallas, TX, USA
 

EMERGING TERAPIES

PSORIASIS

Emerging therapies for psoriasis

Presented by: Prof. Michel Gilliet, Department of Dermatology, Lausanne CHUV, Switzerland

ATOPIC DERMATITIS

New and emerging therapies in atopic dermatitis

Presented by: Prof. Dagmar Simon, Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland

ONYCHOMYCOSIS

Emerging treatments for onychomycosis

Presented by: Dr. Ditte Marie L. Saunte, Department of Dermatology, Institute for Clinical Medicine, Zealand University Hospital, Roskilde, Denmark
 

REVIEW & UPDATES

ACNE & ROSACEA

Isotretinoin for acne and rosacea

Presented by: Dr. Pedro Mendes-Bastos, Dermatology Centre, Hospital CUF Descobertas, Lisbon, Portugal

ALOPECIA AREATA

New drugs for alopecia areata

Presented by: Prof. Spyridon Gkalpakiotis, Department of Dermatovenereology, Third Faculty of Medicine and University Hospital of Kralovske Vinohrady, Prague, Czech Republic.

DERMATOSURGERY

Update in dermatosurgery

Presented by: Prof. Eduardo Nagore, Department of Dermatology, Instituto Valenciano de Oncología, Valencia, Spain

EPIDERMOLYSIS BULLOSA

New start of gene therapy in epidermolysis bullosa

Presented by: Prof. Leena K. Bruckner-Tuderman, University Medical Center, Albert-Ludwigs-University of Freiburg, Germany

MELANOMA

Treatment resistance in metastatic melanoma

Presented by: Prof. Martin Röcken, Department of Dermatology, Eberhard-Karls-University Tübingen, Germany

SCAR TREATMENT

Future of medical scar treatment

Presented by: Prof. Gabriella Fabbrocini, Department of Dermatology, University of Naples Federico II, Naples, Italy
 

EDUCATION FORUM

NON-MELANOMA SKIN CANCER

Systemic treatments of non-melanoma skin cancer

Presented by: Prof. Henrik F. Lorentzen, Department of Dermatology, Aarhus University Hospital, Denmark
 

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